CBD or cannabidiol is deprived of psychoactive properties, but it will help with various diseases
Recently, the main topic of medical marijuana has been surfacing more and more regularly in foreign media, scientists are trying their best to have permissions and funding for research in this region, believing in its promise, and in many countries of the entire world, decriminalization and legalization are underway.
Most hype now causes a substance such as for example CBD or cannabidiol within the hemp plant. Today it is found anywhere – from food to decorative cosmetics and quite legally purchased best cbd gummies uk in online retailers in the form of oil. And all because CBD does not have psychoactive properties, unlike tetrahydrocannabinol (THC), but it has healing properties.
Since CBD is an active part of marijuana itself, you will get make money from it by smoking a joint in the old fashioned way. The most important thing would be to ensure that a quality with a predominance of this specific substance, rather than THC, is clogged in your joint if you would like to relax and relieve anxiety or pain, and not, as usual, get stuck in the couch, unsuccessfully trying to regulate paranoia.
Let’s make an effort to figure out how this magical cannabidiol works, based on the latest data from the entire world of science and the ability of consumers using CBD as a medication, and not for fun.
The difference between the effects of CBD and THC
Since cannabidiol is not just a psychoactive substance, you can’t get high as a result, but it’s easy to boost your productivity, relieve anxiety and relieve pain. When utilizing CBD, thoughts are not confused, memory doesn’t deteriorate, and as a result of muscle relaxation, you may not turn into a vegetable, as is often the case with smoking cannabis varieties with a predominance of THC.
If the ratio of the substances is approximately the same, then you definitely will discover a small euphoric and the above-mentioned beneficial effects at the same time. At once, such negative consequences as paranoia, dry mouth, drying out and redness of the eyes, hunger and gluttony, drowsiness, and short-term memory problems, which are generally caused by THC, do not occur. Such varieties are frequently used as a painkiller.
Although CBD is effective alone, some experts still insist that in combination with other active aspects of marijuana, it brings more benefits:
“To reach an improved therapeutic effect, you’ll need a mixture of cannabidiol, THC, and terpenoid phytochemicals,” says psychiatrist doctor at Harvard Medical School Lester Greenspoon.
However, how exactly this effect is achieved, scientists can not yet say with accuracy. This knowledge gap is caused, first of all, by deficiencies in research data, since the field of studying the healing properties of hemp is still in its infancy. Nevertheless the gradual legalization of medical marijuana shows that scientists will quickly do have more freedom due to their experiments. So hold the fists, hope and believe.
What diseases cannabidiol helps to cope with
Some scientific papers suggest that CBD has anti-inflammatory, analgesic and antipsychotic properties. In this regard, doctors hope this substance may help pharmaceutical companies to develop effective drugs against many disorders and diseases accompanied by similar symptoms.
The set of such diseases includes, but is not limited to such pathological conditions:
To date, there are no full-fledged drugs centered on CBD to combat these disorders, but many patients claim that the substance helps them to ease and even completely get rid of the symptoms.
Recently in the USA, where marijuana is still on the list of the very most dangerous psychoactive substances, there is a huge real breakthrough in the field of pharmaceuticals – the Federal Food and Drug Administration (FDA) has approved the launch of the initial marijuana-based antiepileptic drug on the American market under Epidiolex name.
Its main component is precisely cannabidiol, the anticonvulsant aftereffect of which the FDA has confirmed with its tests. Today, Epidiolex is employed to treat severe forms of epilepsy and such rare disorders that cause frequent and intense cramps in children, like Drave syndrome and Lenno-Gastaut syndrome.
And yet, before Epidiolex, there have been other drugs based on the aspects of marijuana. As an example, the Belgian company Solvay Pharmaceuticals back in 1985 created Marinol (dronabinol), a medication that is simply a manufactured THC, which is still used today to boost the appetite of cancer patients undergoing chemotherapy.
In 2010, British pharmaceutical group GW Pharmaceuticals developed Sativex, a drug containing equal areas of CBD and THC, to alleviate muscle cramps and other symptoms of multiple sclerosis.
The mechanism of action of cannabidiol
Although there is still less data how CBD features a beneficial influence on the body, scientists still have some ideas with this subject. Surprisingly, cannabidiol doesn’t bind to the active sites of the cannabinoid receptors CB1 and CB2, as does the same THC. However it interacts with the GPR55 protein secreted in mental performance and peripheral organs. Researchers believe this determines its antispasmodic effect.
In mental performance, CBD regulates the synaptic transmission process, during which signaling molecules are transmitted from one neuron to another. The connections between these brain cells grow stronger when GPR55 is activated.
Convulsions occur when neurons become too active in signaling, flashing more regularly than necessary. Cannabidiol blocks the GPR55 protein, thus preventing overload of the synaptic transmission system, in accordance with Ben Wally, head of research at GW Pharmaceuticals.
The connection with this protein with CBD is confirmed by experiments with genetically modified rodents where epileptic seizures were caused. Those animals where GPR55 was present responded to cannabidiol treatment, and rats without protein continued to see convulsions.
Wally also believes that CBD can subscribe to the desensitization of the TRPV1 protein, which is involved in the transport of ions and calcium in the torso, which also helps relieve cramping. First, cannabidiol activates this protein, however quickly decreases the sensitivity of the ion channel, effectively blocking the transport of calcium into cells. By analogy with GPR55, animals that lack TRPV1 do not respond to CBD.
Finally, this substance interacts with the channel of transport of adenosine, an anticonvulsant substance made by the body. Wally believes that cannabidiol suppresses seizures, mainly due to its influence on adenosine, but more experiments are required to ensure this hypothesis.
This kind of wide variety of areas where CBD is active allows scientists to suggest this substance might be useful in the treatment of motor disorders, such as for example Parkinson’s disease. And the interaction with serotonin receptors shows that cannabidiol can be used to treat depression, anxiety and psychotic stages of bipolar disorder and schizophrenia.
Nevertheless, many researchers, such as for example Roger Pertwee, a professor at the University of Aberdeen and the pinnacle of the pharmacology department of GW Pharmaceuticals, insist that without clinical data it cannot be confidently stated that the interaction of CBD with these receptors and proteins means so it causes a therapeutic aftereffect of this substance.
High CBD Marijuana Varieties
Finally, we provides you with a list of popular cannabidiol-dominated varieties so guess what happens to enquire about next time in your telegram supermarket: